Expression data of tigecycline-treated liver cancer cells. Expression data of tigecycline-treated liver cancer cells

Treatment of advanced liver cancer still faces great challenges. Identification of tumor dependencies is important for developing novel therapeutic strategies for liver cancer. Here, we identified mitochondrial translation as a major vulnerability of liver cancer by genome-wide CRISPR screen. Targeting mitochondrial translation by tigecycline showed therapeutic potential in liver cancer. While some liver cancer cells were extremely insensitive to tigecycline.Thus,RNA sequencing was performed to explore mechanisms. Overall design: mRNA profiles of MHCC97H and PLC/PRF/5 cells treated with tigecycline.