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Published Orthogonal Replication, Exact Response Algebra, Dominant-Dual Falsification Simplex, and Strict Same-Core Falsification Protocol of a Native Fracture-State Family in a Computational Longevity Discovery Pipeline (Trinity Claims #87-#118, 2026-03-26)

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Zenodo2026-03-27 更新2026-05-26 收录
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This version fixes the next mechanistic and experimental milestone from the Trinity computational longevity-discovery pipeline. Claims #87-#118 establish an exact operational plateau for native fracture-state admission, orthogonal replication of the target TOP3A/RMI2/CCDC69 family in published huMAP3 layers, selectivity and explicit taxonomy of the analyzable published split-family background, strong-core switch decomposition, an arm-polarized fracture axis, flat-to-polarized amplification, cryptic stable hierarchy, top-arm conservation, dual-collapse taxonomy, permutation rigidity, exact three-term response algebra, a phase-83 dominant-dual falsification simplex, and a final phase-84 strict falsification protocol that preregisters the first same-core wet-lab decision surface. The target now implies a locked acceptance geometry: RMI2_share > TOP3A_share > CCDC69_share, RMI2_share + TOP3A_share >= 0.95, CCDC69_share <= 0.05, and RMI2_share - TOP3A_share >= 0.05. The package also freezes explicit rejection classes: ceiling-only residue, symmetric dual repair, bridge-first inversion, and diffuse control leak. This package contains the milestone report, claim documents, phase reports, summary tables, protocol tables, source files, the fracture-aware generator source, and the wet-lab/falsification materials needed to score the first same-core experiment without post hoc reinterpretation. This is a computational discovery and preregistration package and not a completed causal validation study.

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2026-03-27
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