Gene expression changes in mouse breast cancer cells (4T1) after axitinib resistance. Gene expression changes in mouse breast cancer cells (4T1) after axitinib resistance

RNA sequencing analysis was used to identify changes in mouse breast cancer cells (4T1) resistant to axitinib (AxR). Overall design: Mouse breast cancer cells (4T1) resistant to axitinib were derived in vivo after continuous treatment with 100mg/kg/day axitinib from post-surgical metastatic lesions. Resistant cells were maintained in vitro with 0.5μM axitinib for more than 2 months.