Crystal structure of MAT2a with triazinone fragment 1 bound in the allosteric site

Protein Data Bank Japan2024-05-01 更新2026-03-21 收录

下载链接：

https://pdbj.org/mine/summary/7bhr

下载链接

链接失效反馈

官方服务：

资源简介：

Crystal structure of MAT2a with triazinone fragment 1 bound in the allosteric site Descriptor: 4-(dimethylamino)-6-ethoxy-1~{H}-1,3,5-triazin-2-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 Authors: Schimpl, M, De Fusco, C, Borjesson, U, Cheung, T, Collie, I, Evans, L, Narasimhan, P, Stubbs, C, Vazquez-Chantada, M, Wagner, D.J, Grondine, M, Tentarelli, S, Underwood, E, Argyrou, A, Bagal, S, Chiarparin, E, Robb, G, Scott, J.S. Deposit date: 2021-01-11 Release date: 2021-04-21 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.08 Å) Cite: Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model. J.Med.Chem., 64, 2021

结合于变构位点的三嗪酮片段1与MAT2a的晶体结构描述组分：4-(二甲氨基)-6-乙氧基-1H-1,3,5-三嗪-2-酮、S-腺苷甲硫氨酸（S-adenosylmethionine）、S-腺苷甲硫氨酸合酶亚型2型作者：Schimpl, M、De Fusco, C、Borjesson, U、Cheung, T、Collie, I、Evans, L、Narasimhan, P、Stubbs, C、Vazquez-Chantada, M、Wagner, D.J、Grondine, M、Tentarelli, S、Underwood, E、Argyrou, A、Bagal, S、Chiarparin, E、Robb, G、Scott, J.S. 保藏日期：2021-01-11 发布日期：2021-04-21 最后修改日期：2024-05-01 测定方法：X射线衍射（1.08埃）引用文献：《基于片段设计的强效MAT2a抑制剂及其在MTAP缺失异种移植模型中的体内评价》，《药物化学杂志》，64卷，2021年

创建时间：

2021-01-11