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Enantioselective Synthesis of Ring-Fused Spiroannulated 1,2,3-Thiadiazole Derivatives

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NIAID Data Ecosystem2026-03-09 收录
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An organocatalytic enantioselective domino α-amination/oxidative coupling/cyclization of thioamides to azodicarboxylates catalyzed by an easily available organic catalyst has been developed. The key step, oxidative coupling, is smoothly fulfilled in air. Optically active spiroannulated 1,2,3-thiadiazole derivatives are obtained with high yields and enantioselectivities for the first time.

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2016-05-02
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