TGF-β neutralization attenuates tumor residency of activated T cells to enhance systemic immunity in mice

NIAID Data Ecosystem2026-05-02 收录

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https://zenodo.org/record/12550791

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Deep TCR sequencing was performed using the TCR Profiling Kit from MiLaboratories (Mouse α/β TCR RNA; Kit MiLaboratories; TMMR-001). Deep TCR sequencing was analyzed using the MiXCR software from MiLaboratories per manufacturer's recommendations. The files correspond to the TCR-beta sequences.The files are named as follows: file_name cell type sequenced tissue of origin treatment mouse_id 21BA1dLN.clones_TRB.tsv T cells tumor-draining lymph node bintrafusp alpha 1 23BA2dLN.clones_TRB.tsv T cells tumor-draining lymph node bintrafusp alpha 2 25BA3dLN.clones_TRB.tsv T cells tumor-draining lymph node bintrafusp alpha 3 27BA4dLN.clones_TRB.tsv T cells tumor-draining lymph node bintrafusp alpha 4 29BA5dLN.clones_TRB.tsv T cells tumor-draining lymph node bintrafusp alpha 5 22BA1SP.clones_TRB.tsv T cells spleen bintrafusp alpha 1 24BA2SP.clones_TRB.tsv T cells spleen bintrafusp alpha 2 26BA3SP.clones_TRB.tsv T cells spleen bintrafusp alpha 3 28BA4SP.clones_TRB.tsv T cells spleen bintrafusp alpha 4 30BA5SP.clones_TRB.tsv T cells spleen bintrafusp alpha 5 31CON1dLN.clones_TRB.tsv T cells tumor-draining lymph node control 6 33CON2dLN.clones_TRB.tsv T cells tumor-draining lymph node control 7 35CON3dLN.clones_TRB.tsv T cells tumor-draining lymph node control 8 37CON4dLN.clones_TRB.tsv T cells tumor-draining lymph node control 9 39CON5dLN.clones_TRB.tsv T cells tumor-draining lymph node control 10 32CON1SP.clones_TRB.tsv T cells spleen control 6 34CON2SP.clones_TRB.tsv T cells spleen control 7 36CON3SP.clones_TRB.tsv T cells spleen control 8 38CON4SP.clones_TRB.tsv T cells spleen control 9 40CON5SP.clones_TRB.tsv T cells spleen control 10 1aPDL11dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-PDL1 antibody 11 3aPDL12dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-PDL1 antibody 12 5aPDL13dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-PDL1 antibody 13 7aPDL14dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-PDL1 antibody 14 9aPDL15dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-PDL1 antibody 15 2aPDL11SP.clones_TRB.tsv T cells spleen anti-PDL1 antibody 11 4aPDL12SP.clones_TRB.tsv T cells spleen anti-PDL1 antibody 12 6aPDL13SP.clones_TRB.tsv T cells spleen anti-PDL1 antibody 13 8aPDL14SP.clones_TRB.tsv T cells spleen anti-PDL1 antibody 14 10aPDL15SP.clones_TRB.tsv T cells spleen anti-PDL1 antibody 15 11aTGFB1dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-TGF-beta antibody 16 13aTGFB2dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-TGF-beta antibody 17 15aTGFB3dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-TGF-beta antibody 18 17aTGFB4dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-TGF-beta antibody 19 19aTGFB5dLN.clones_TRB.tsv T cells tumor-draining lymph node anti-TGF-beta antibody 20 12aTGFB1SP.clones_TRB.tsv T cells spleen anti-TGF-beta antibody 16 14aTGFB2SP.clones_TRB.tsv T cells spleen anti-TGF-beta antibody 17 16aTGFB3SP.clones_TRB.tsv T cells spleen anti-TGF-beta antibody 18 18aTGFB4SP.clones_TRB.tsv T cells spleen anti-TGF-beta antibody 19 20aTGFB5SP.clones_TRB.tsv T cells spleen anti-TGF-beta antibody 20

创建时间：

2024-07-05