Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically-inflamed intestine. Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically-inflamed intestine

The goal of this study was to identify differences in intestinal regulatory T cell gene expression in male and female mice lacking ESR2 (estrogen receptor beta), compared to those expressing ESR2. Overall design: Sequencing of regulatory T cells from male versus female SAMP mice expressing or lacking global expression of ESR2.