silencing of endogenous Dnmt3L in Tg-Miwi2P-asDnmt3L mice. Mus musculus
收藏NIAID Data Ecosystem2026-03-14 收录
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资源简介：
We produced the transgenic mice expressing antisense-Dnmt3L under the Miwi2 promoter (Tg-Miwi2P-asDnmt3L).Tg-Miwi2P-asDnmt3L mice showed reduced endogenous Dnmt3L RNA expression and a phenotype quite similar to that of DNMT3L-difficient mice. We examined the genomic insertion sites of transgene to clarify the mechanism of piRNA-mediated silencing.
创建时间：
2022-10-28
