Comparative Methylome Analyses Reveal Human Brain Specific Methylated Regions Implicated in Transcription Regulation

To gain further insights into human brain specific epigenetic changes, we generated whole genome bisulfite sequencing methylation maps (methylomes) of rhesus macaque brains. These were then compared to methylomes of human and chimpanzee brains that were previously generated. We then performed validation experiments using targeted bisulfite sequencing. Overall design: Bisulfite-seq in prefrontal cortext of two male Macaca mulatta