A concise and stereoselective total synthesis of (−)-salinosporamide A (1), a potent inhibitor of the 20S proteasome that is in clinical development as an anticancer drug candidate, has been accomplis
Targeting the protein–protein interaction between p53 and MDM2/MDMX (MDM4) represents an attractive anticancer strategy for the treatment of p53-competent tumors. Several selective and potent MDM2 inh
The environmentally sustainable synthesis of nanoparticles has arisen as a viable alternative to traditional methods, tackling ecological and economic issues. This research investigates the green synt
Project title:Production, characterization, and application of L-asparaginases from indigenous marine bacteria of the Arabian Gulf, Saudi ArabiaAuthors:Ghofran M. AL-Harbi, Essam K. Ghareeb, Ebtesam A
The ERCC1–XPF heterodimer is a 5′–3′ structure-specific endonuclease, which plays an essential role in several DNA repair pathways in mammalian cells. ERCC1–XPF is primarily involved in the repair of
