Type III IFN signaling pathway

Figure 1. Type III IFN signaling pathway. Viral infection is sensed by pattern recognition receptors (PRRs), which induce IFN-? production via various signaling pathways. IFN-?s bind to the heterodimeric IFN-? receptor (IFNLR), which consists of IL28RA and IL10RB subunits. Upon binding, a JAK?STAT signaling cascade induces hundreds of IFN-stimulated genes (ISGs). RLR, RIG-1-like receptor; TLR, toll-like receptors; NF-?B, nuclear factor kappa-light-chain-enhancer of activated B cells; IL28RA, interleukin 28 receptor alpha; IL10RB, interleukin 10 receptor beta; JAK1, Janus Kinase 1; TYK2, tyrosine kinase 2; STAT, signal transducer and activator of transcription; IRF, interferon regulatory factor; ISRE, interferon-stimulated response element; MX1, interferon-induced GTP-binding protein Mx1; OAS1, 2?-5?-oligoadenylate synthetase..