Transcriptional response of thyroid to iodide in wild-type and Nrf2 knockout mice

Analysis of differentially expressed mRNAs indicated that iodide overload upregulated inflammatory-, immune-, fibrosis- and oxidative stress-related pathways, including the Nrf2 pathway. Nrf2 KO mice showed a more pronounced inflammatory-autoimmune transcriptional response to iodide Thyroidal mRNA profiles after iodide exposure (0.05% NaI in their drinking water for 7 days) in C57Bl6j WT and Nrf2 knockout mice