Comparison of the prediction performance of SIFT, PolyPhen, and PANTHER.

aSensitivity = true positive/(true positive+false negative) bSpecificity = true negative/(true negative+false positive) cPositive predictive value = true positive/(true positive+false positive) dCorrelation coefficient = (true positive×true positive−false positive×false negative)/((true positive+false positive) (true positive+false negative) (true negative+false positive)(true negative+false negative))1/2 eTrue-positive cost = false positive/true positive