Crystal Structure of Hsp90-alpha N-domain in complex 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-isopropyl-N-methyl-benzenesulfonamide

Protein Data Bank Japan2024-01-10 更新2026-03-21 收录

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Crystal Structure of Hsp90-alpha N-domain in complex 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-isopropyl-N-methyl-benzenesulfonamide Descriptor: 5-[4-(2-fluorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]-2,4-dihydroxy-N-methyl-N-(propan-2-yl)benzene-1-sulfonamide, Heat shock protein HSP 90-alpha Authors: Amaral, M, Matias, P. Deposit date: 2016-04-07 Release date: 2017-12-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Protein conformational flexibility modulates kinetics and thermodynamics of drug binding. Nat Commun, 8, 2017

热休克蛋白HSP 90-α（Heat shock protein HSP 90-alpha）N结构域与5-[4-(2-氟苯基)-5-氧代-4,5-二氢-1H-[1,2,4]三唑-3-基]-2,4-二羟基-N-异丙基-N-甲基苯磺酰胺结合复合物的晶体结构描述符：5-[4-(2-氟苯基)-5-氧代-4,5-二氢-1H-1,2,4-三唑-3-基]-2,4-二羟基-N-甲基-N-(异丙基)苯-1-磺酰胺作者：Amaral M、Matias P 提交日期：2016-04-07 发布日期：2017-12-06 最后修改日期：2024-01-10 测试方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.17埃引用文献：《Protein conformational flexibility modulates kinetics and thermodynamics of drug binding》，《自然·通讯》，2017年，第8卷

创建时间：

2016-04-07