Gene expression profiling of fucose-deficient Fx-/- mice cDC1-enriched splenocytes
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE163958
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Analysis of the top differentially regulated genes in cDC1 in response to fucose treatment revealed genes enriched in pathways such as immune-effector processes, myeloid leukocyte activation, exocytosis, and secretion. We used microarrays to detail the global programme of gene expression underlying fucosylation deficiency in mouse cDC1 cells cDC1 cells were isolated from mouse spleens by negative selection with biotinylated B220 and CD11b antibody and anti-Biotin MicroBeads followed by positive selection with CD11c MicroBeads. Total RNA was extracted from spleen cDC1 cells, reverse transcribed and labeled according to the instruction of Affymetrix WT Pico protocol
创建时间：
2021-03-10
