Animal experiments of caloric restriction diet and cancer.

aTime: Time of study (weeks); bC: Conclusion of the study, “+” indicates a positive conclusion and “-” represents a negative conclusion; cQ: Quality of the study according to a critical checklist of the Stroke Therapy Academic Industry Roundtable; dS: The step(s) of cancer that dietary restriction regimens interfere during the initiation, progression and metastasis of cancer, “I” indicates initiation, “P” indicates progression and “M” indicates metastasis; eTG: transgenic; fAL: Ad libitum; gCR: caloric restriction; hw: week; iC: Chemical-induced; jICR: Intermittent caloric restriction; kCCR: chronic caloric restriction; l25/32.5: ICR mice sacrificed at the end of the 12th restriction period/ICR mice sacrificed at 1week after 12th refeeding; mTP: transplanted; n/: not specified; oLate-onset 20%CR: al libitum 20 weeks followed by 20% diet restriction; p27.43/30.89: Mice euthanized during restriction/Mice euthanized during AL consumption; qS: Spontaneous.Animal experiments of caloric restriction diet and cancer.