Mathematical models of cardiac ion channels have been widely used to study and predict the behaviour of ion currents. Typically models are built using biophysically-based mechanistic principles such a
Intracellular calcium ([Ca2+]i) is a basic and ubiquitous cellular signal controlling a wide variety of biological processes. A remarkable example is the steering of sea urchin spermatozoa towards the
Appendix. A0 Mean and Covariance as a Function of Kinetic Model Parameters. A1 Linear Algebra Algorithms for Semiseparable Matrices. A2 Log-likelihood Gradient. A3 Log-likelihood Calculation in the Ca
