Loss of Ten-Eleven Translocation 2 Exacerbates allergic inflammation by 5-Hydroxymethylcytosine Remodeling in Immunologic Pathways

Here we show that loss of ten-eleven translocation protein (Tet2) could impact the severity of allergic rhinitis (AR) in ovalbumin-induced mouse model. Genome-wide 5hmC profiling of wildtype, Tet2+/- and Tet2-/- mice in response to AR revealed that the loss of Tet2 could lead to the 5hmC alteration at specific immune response genes on RNA-seq. Nasal mucosa mRNA profiles and 5hmC captured ChiP-seq profiles of adult wild type (WT), Tet2 +/- and Tet2-/- mice in allergic rhinitis or control conditions.