Additional file 24 of Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS

Additional file 24. Treatment preparation-specific prediction of the presence of nADA in the replication data. Eight PRS, the top single GWAS variant, and the top HLA allele from the discovery stage were analyzed in the replication data using the covariates sex, age, treatment preparation, treatment duration, titration site, and eight ancestry components. Upper table: Prediction of the presence of nADA in IFNβ-1a s.c.-treated patients from the replication data using all ten prediction models based on analyses for IFNβ-1a s.c. in the discovery data. Lower table: Prediction of the presence of nADA in IFNβ-1b s.c.-treated patients from the replication data using all ten prediction models based on analyses for IFNβ-1b s.c. in the discovery data. Beta = regression effect size, SE = standard error, P = p-value.