Evolutionary study of Metalloproteinases

This dataset is the product of the article entitled Metalloproteinases in restorative dentistry: an in silico study for an ideal animal model.
Abstract:
Dentin degradation, providing restorative procedures with greater longevity. Among MMPs, collagenases and gelatinases are intrinsic constituents of the fibrillar network of the organic matrix of human dentin and are the most abundant MMPs in this tissue. In this study, we were able to obtain 176,077 sequences of mammalian MMPs from the UNIPROT database. After data curation, 3,178 sequences were aligned and used in phylogenetic reconstruction to search for the model organism evolutionarily closest to humans. We were also able to annotate (n=235) and re-annotate (n=27) several MMP sequences. In our results we were able to infer the most appropriate model organisms for studies in restorative dentistry for collagenases and gelatinases.