Expression data from iPSC-derived mimetic Vγ9Vδ2 T cells and mimetic NK cells

We designed and demonstrated a synthetic strategy to derive mimetic Vγ9Vδ2 T cells endowed with NKRs from iPSCs. We used microarrays to compare mRNA expression profiles of such iPSC-derived mimetic Vγ9Vδ2 T cells with other peripheral blood lymphocytes. We reprogrammed γδ T cell into iPSCs (γδ T-iPSCs) and then used an “NK cell-promoting” protocol to differentiate γδ T-iPSCs and to induce expression of natural killer receptors (NKRs). RNA was extracted from such produce iPSC-derived mimetic Vγ9Vδ2 T cells and hybridized on microarray.