Crystal structure of Q78R mutant human PTP1B (PTPN1) at room temperature (298 K)

Crystal structure of Q78R mutant human PTP1B (PTPN1) at room temperature (298 K) Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Shah, D.S, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. Deposit date: 2024-08-02 Release date: 2024-08-21 Last modified: 2025-12-10 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites. J.Biol.Chem., 301, 2025

室温（298 K）下Q78R突变型人源蛋白酪氨酸磷酸酶1B（PTP1B，PTPN1）的晶体结构。描述符：镁离子、非受体型酪氨酸蛋白磷酸酶1型。作者：Ebrahim A、Perdikari A、Woods V.A、Lawler K、Bounds R、Shah D.S、Singh N.I、Mehlman T、Riley B.T、Sharma S、Morris J.W、Keogh J.M、Henning E、Smith M、Farooqi I.S、Keedy D.A。提交日期：2024-08-02；发布日期：2024-08-21；最后修改日期：2025-12-10。实验方法：X射线衍射（2.3 Å）。引用文献：《人源蛋白酪氨酸磷酸酶变体的结构揭示可靶向变构位点》，《J. Biol. Chem.》，第301卷，2025年。