Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)

Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) Descriptor: 1,2-ETHANEDIOL, 1-(TERT-BUTYL)-3-(QUINOXALIN-6-YL)UREA, NITRATE ION, ... Authors: Silva-Santisteban, M.C, Westwood, I.M, Boxall, K, Brown, N, Peacock, S, McAndrew, C, Barrie, E, Richards, M, Mirza, A, Oliver, A.W, Burke, R, Hoelder, S, Jones, K, Aherne, G.W, Blagg, J, Collins, I, Garrett, M.D, van Montfort, R.L.M. Deposit date: 2012-10-05 Release date: 2013-06-26 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. Plos One, 8, 2013

基于片段的筛选发现检查点激酶2（checkpoint kinase 2, CHK2）抑制剂结合的新区域
描述物：1,2-乙二醇，1-(叔丁基)-3-(喹喔啉-6-基)脲，硝酸根离子，……
作者：Silva-Santisteban, M.C.、Westwood, I.M.、Boxall, K.、Brown, N.、Peacock, S.、McAndrew, C.、Barrie, E.、Richards, M.、Mirza, A.、Oliver, A.W.、Burke, R.、Hoelder, S.、Jones, K.、Aherne, G.W.、Blagg, J.、Collins, I.、Garrett, M.D.、van Montfort, R.L.M.
提交日期：2012-10-05
发布日期：2013-06-26
最后修改日期：2023-12-20
实验方法：X射线衍射（分辨率2.67埃）
引用文献：《基于片段的筛选绘制检查点激酶2 ATP结合位点内的抑制剂相互作用图谱》，发表于《公共科学图书馆·综合（PLOS ONE）》，2013年，第8卷。