Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

Data from ProteomeXchange, PXD ID: PXD001495. File: ELITE-RSLC001519.mzml. From ProteomeXchange: {{i}} ... Here we show a comprehensive picture of the changes in the cellular transcriptome and proteome in response to the stress associated with protein import dysfunction. We identify pathways that protect the cell against mitochondrial biogenesis defects by inhibiting protein synthesis and by activation of the proteasome, a major machine for cellular protein clearance ... {{/i}}