p-Y516 of p-5Y-NTRK2 recruits SHC1

Autophosphorylated tyrosine Y516 of NTRK2 (corresponds to Y515 of the full-length mouse Ntrk2 and Y484 of the mature rat Ntrk2) is a docking site for SHC1 isoforms p52 (SHC1-2) and p46 (SHC1-3), which function as activators of RAS signaling (Minichiello et al. 1998, McCarthy and Feinstein 1998, McCarthy and Feinstein 1999). SHC1 is recruited to Y516 of NTRK2 in response to BDNF stimulation (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999) and NTF4 stimulation (Minichiello et al. 1998, Yuen and Mobley 1999). Recruitment of SHC1 to NTRK2 in response to stimulation by NTF3 has not been examined.

自磷酸化酪氨酸Y516位于NTRK2蛋白（对应于全长小鼠Ntrk2的Y515和成熟大鼠Ntrk2的Y484）上，此位点为SHC1异构体p52（SHC1-2）和p46（SHC1-3）提供结合位点，而SHC1异构体作为RAS信号通路的激活因子（Minichiello等，1998年，McCarthy和Feinstein，1998年，McCarthy和Feinstein，1999年）。在BDNF刺激（Minichiello等，1998年，McCarthy和Feinstein，1999年，Yuen和Mobley，1999年）和NTF4刺激（Minichiello等，1998年，Yuen和Mobley，1999年）的诱导下，SHC1被招募至NTRK2的Y516位点。然而，对于NTF3刺激下SHC1对NTRK2的招募尚未进行探讨。