Best fit parameters for the biphasic activation-inhibition dose-response curves (eqn. 1)a.

The units for all activity measurements are: Aβ 1-40 secreted in pM per 106 cells.athe best fit values ± standard error were calculated using nonlinear regression and eqn. 1.btwo sigma confidence intervals as described in methods section.cthe initial activity (IA) and the maximal inhibition (MA) can be measured separately with high confidence, and thus taken as constants in nonlinear regression. This can give significantly sharper two sigma confidence intervals and standard errors, due to increase in the number of degrees of freedom [34].