ZHX3 is a transcriptional factor whose role in human pancreatic beta cells is not well understood. In attempt to identify the genes that ZHX3 regulates in beta cells, we KO ZHX3 using CRISPR in EndoC-

NIAID Data Ecosystem50

Effect of NR4A3 siRNA treatment on gene expression of islet derived hybrid cell of 1.1B4

胰腺β细胞基因调控

NR4A3功能基因组学

Gene regulation associated with antioxidant defense system in pancreatic beta cells still needs to be elucidated, we found NR4A3 gene expression was up-regulated with 100mM H2O2, therefore, we analyze

NIAID Data Ecosystem30

MAFB ChIPseq in Human EndoCBH2 cells. MAFB ChIPseq in Human EndoCBH2 cells

ChIP-seq分析

胰腺β细胞基因调控

The intent of this experiment was to determine MAFB binding sites in human pancreatic beta cells. This is particularly relevant as MAFB is not expressed in mature rodent beta cells; thus, it may perfo

NIAID Data Ecosystem70

Genome-wide assessment of Nkx2.2 binding sites in MIN6 pancreatic beta cell line

转录因子结合位点

胰腺β细胞基因调控

Through ChIP-Seq analysis we found Nkx2.2 to bind to important beta cell genes as well as to non beta endocrine ones. Overall design: Examination of Nkx2.2 binding sites in MIN6 pancreatic beta cell l

NIAID Data Ecosystem30

Chromatin immunoprecipitation of mouse MIN6 pancreatic beta cells to identify Pdx1 targets

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