Tetramer annotation of cleavage sites in MMP-2 and 9 substrates collected from the MEROPS database.

The data have been divided into two groups–those annotated as physiologic substrates (A)–MMP2, (C)–MMP9, and all substrates (B)–MMP2, (D)–MMP9. Each table contains information about octamer sequences covering P4-P4՛ positions of substrates as reported in MEROPS, the corresponding tetramers, their ranks and relative probabilities, as well as MEROPS annotation relating the cleavage site to its position in a protein or analyzed polypeptide. Tab (E) General Statistics–contains information about the number of all and physiologic substrates found in MEROPS that have their RP values above the corresponding selectome thresholds for MMP-2 and 9 enzymes. Tab F contain information about the common set of MMP-2 and 9 physiologic substrates found in MEROPS. The P3-P1՛ tetramer rankings and corresponding RP values are provided for both MMP-2 and 9 together with corresponding correlation plot between RP values. The tabs G and H contain the same type of information, as in the Tab F, for unique physiologic substrates for MMP-2 and 9, respectively. (XLSX)