Single cell transcriptomic landscape of pediatric B-cell acute lymphoblastic leukemia: dissection of transcriptional heterogeneity and B-cell developmental state

Genomic analyses of bulk ALL samples have improved our understanding of the genetic basis and risk stratification of B-cell acute lymphoblastic leukemia (B-ALL), but do not directly examine intratumor heterogeneity or enable inference of leukemia developmental state and cell of origin. In this study we profiled 89 B-ALL samples by single-cell RNA-seq (scRNA-seq) (10X Genomics 5’v2) to investigate transcriptional heterogeneity and developmental states of leukemic cells. We profiled 89 B-ALL samples by single-cell RNA-seq (scRNA-seq) (10X Genomics 5’v2) and compared them to a scRNA-seq reference map of normal human B-cell development. **Submitter states that clinical description will be provided in the corresponding publication as supplemental tables, if relevant to the study's conclusion** **Raw data were submitted to EGA under accession number EGAS00001007512**