Improvements in Methyl-Bambus[6]uril Synthesis Yield

Bambus[n]uril synthesis may be challenging, and it is frequently achieved with low purity and low yields. We have studied the effect of different anions on the synthesis of bambus[6]uril, especially in terms of yield, exploring template effects driven by anions in the reaction medium. The influence of the anions is evident on such syntheses and ClO4− particularly led to unprecedented synthesis yields. Computational calculations have also been used to elucidate the influence of anions on cyclization process.葫芦[n]脲(Bambus[n]uril)的合成往往颇具挑战，且通常产物纯度与收率均较低。我们针对不同阴离子对葫芦[6]脲(Bambus[6]uril)合成的影响展开了系统研究，重点关注收率指标，并探索了反应介质中阴离子驱动的模板效应。阴离子对该类合成过程的影响十分显著，其中高氯酸根(ClO4−)更实现了前所未有的合成收率。本研究同时借助计算模拟手段，阐明了阴离子对环化反应过程的影响。