GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset)

GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset) Descriptor: (2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-5-thio-alpha-D-galactopyranose, ... Authors: Lira-Navarrete, E, Iglesias-Fernandez, J, Zandberg, W.F, Companon, I, Kong, Y, Corzana, F, Pinto, B.M, Clausen, H, Peregrina, J.M, Vocadlo, D, Rovira, C, Hurtado-Guerrero, R. Deposit date: 2014-04-30 Release date: 2014-05-28 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2. Angew.Chem.Int.Ed.Engl., 53, 2014

经尿苷二磷酸-5-硫代-N-乙酰半乳糖胺（UDP-5SGalNAc）、mEA2及锰离子浸泡的多肽N-乙酰半乳糖胺基转移酶2（GalNAc-T2）晶体数据集（高分辨率数据集）
描述物：(2R,3R,4R,5R,6R)-3-(乙酰氨基)-4,5-二羟基-6-(羟甲基)四氢-2H-硫代吡喃-2-基 [(2R,3S,4R,5R)-5-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)-3,4-二羟基四氢呋喃-2-基]甲基二氢二磷酸酯、1,2-乙二醇、2-乙酰氨基-2-脱氧-5-硫代-α-D-吡喃半乳糖等
作者：Lira-Navarrete, E、Iglesias-Fernandez, J、Zandberg, W.F、Companon, I、Kong, Y、Corzana, F、Pinto, B.M、Clausen, H、Peregrina, J.M、Vocadlo, D、Rovira, C、Hurtado-Guerrero, R
入库日期：2014-04-30
发布日期：2014-05-28
最后修改日期：2024-10-23
检测方法：X射线衍射（分辨率2.2 Å）
引用文献：结合结构快照与元动力学分析揭示多肽N-乙酰半乳糖胺基转移酶2的底物引导正面反应. 《德国应用化学国际版（Angew.Chem.Int.Ed.Engl.）》, 53卷, 2014年