Replication Data for: How the heterogeneity of the severely injured brain affects hybrid diffuse optical signals: case examples and guidelines

Wide-spread adoption of diffuse optics in clinical settings for head injury assessment has been hindered by several factors. First, results from commercially available near-infrared spectroscopy (NIRS) devices often lack reproducibility and may produce physiologically implausible values.
Second, significant variability exists between different systems. These limitations can be partially attributed to the physics of continuous-wave light sources, but a major culprit is the inherent heterogeneity of the head, including morphological and functional abnormalities within the tissue being probed. Our study aimed to investigate the impact of atypical tissue in injured brains on DO signals and to develop recommendations for
avoiding data misinterpretation. Diffuse optical measurements and computed tomography (CT) scans were obtained from patients with brain injuries and stroke. The relationship between the diffuse optical signals and the underlying tissue types was analyzed on an individual patient basis.