Quantitative acetylomics reveals substrates of lysine acetyltransferase GCN5 in adult and aging Drosophila. Quantitative acetylomics reveals substrates of lysine acetyltransferase GCN5 in adult and aging Drosophila

Drosophila GCN5 activity profoundly impacts gene expression. Overall design: We conducted poly-A selected RNA-Seq experiments and explored the dynamics of gene expression during aging process (using heads and muscles of WT (5905) Drosophila at age of 3d, 15d, 30d, and 45d); We further conducted poly-A selected RNA-Seq experiments and explored the role of GCN5 on gene expression (using whole flies of WT (5905), gcn5 loss-of-function, and GCN5 overexpression Drosophila at age of 3d).