We report the application of in situ Hi-C technology to 40 colorectal cancer patients and 10 paired-normal tissue to identify CRC specific changes in 3D chromatin structure. The chromatin contact matr
a compared to lin-17(n671) b compared to lin-17(n671); gfp(RNAi) c compared to lin-18(e620) d compared to lin-18(e620); gfp(RNAi) Animals were grown at 23°C and scored by DIC at late L4 stage. n is nu
Changes in gene expression are a critical force driving the evolution of form and function. As a result, the mechanisms by which gene expression evolves have become a subject of intense interest. A nu
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of