Tanzawaic acid derivatives suppress osteoclastogenesis and osteoporosis via down-regulation of NF-κB and NFATc1 activation
收藏数字南海2024-03-01 收录
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(5S,6R,8R)-Penitanzacid G (6): pale yellow oil; [α]25 D +103 (c 0.1, MeOH); UV (MeOH) λmax (log ε) 200 (4.32), 245 (3.91), 290 (3.94) nm; ECD (0.15 mg/mL, MeOH) λmax (Δε) 240 (−2.13), 288 (+8.92) nm; IR (film) νmax 3383, 2922, 1697, 1683, 1627, 1244, 1182, 1140, 1022, 999, 823, 761 cm−1; 1H and 13C NMR data, Table S2; HRESIMS m/z 301.1449 [M − H]− (calcd for C18H21O4, 301.1445), 603.2967 [2M − H]− (calcd for C36H43O8, 603.2963).
