Crystal structure of BCL-XL bound to compound 15: (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid

Crystal structure of BCL-XL bound to compound 15: (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid Descriptor: (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ... Authors: Roy, M.J, Lessene, G, Czabotar, P.E. Deposit date: 2019-11-02 Release date: 2021-05-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64, 2021

与化合物15结合的BCL-XL（B细胞淋巴瘤因子2样蛋白1）晶体结构：(R)-2-(3-(2-((4'-氯-[1,1'-联苯]-2-基)甲基)-1,2,3,4-四氢异喹啉-6-甲酰基)-3-(4-甲基苄基)脲基)-3-((环己基甲基)磺酰基)丙酸
描述对象：(R)-2-(3-(2-((4'-氯-[1,1'-联苯]-2-基)甲基)-1,2,3,4-四氢异喹啉-6-甲酰基)-3-(4-甲基苄基)脲基)-3-((环己基甲基)磺酰基)丙酸、1,2-乙二醇、B细胞淋巴瘤因子2样蛋白1（Bcl-2-like protein 1）……
作者：Roy, M.J.、Lessene, G.、Czabotar, P.E.
存放日期：2019-11-02
发布日期：2021-05-05
最后修改日期：2023-10-11
检测方法：X射线衍射（分辨率2.19 Å）
引用文献：《结构导向开发强效BCL-XL与BCL-2苯甲酰脲类抑制剂》，《药物化学杂志》（J.Med.Chem.），第64卷，2021年