Associations of MTNR1B SNPs rs10830963 and rs3781638 with anthropometrics, insulin sensitivity, and insulin secretion (N = 1578).

Data represent means��SD. For statistical analysis, data were log-transformed and adjusted. BMI, body fat, and waist circumference were adjusted for gender and age. Plasma glucose levels, indices of insulin sensitivity, and the disposition index were adjusted for gender, age, and BMI. Other indices of insulin secretion were adjusted for gender, age, BMI, and ISI (OGTT). p1�Cp-value after adjustment as described; p2�Cp-value after additional adjustment for family history of diabetes. Significance levels withstanding Bonferroni correction for multiple comparisons are marked in bold letters. AUC�Carea under the curve; HOMA-IR�Chomeostasis model assessment of insulin resistance; ISI�Cinsulin sensitivity index; SNP�Csingle nucleotide polymorphism. *subgroup (N = 513).