ETS1 suppresses tumorigenicity of human colon cancer cells.
收藏PubMed Central1995-05-09 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC41960/
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资源简介：
We have ectopically expressed transcription factor ETS1 in two different highly tumorigenic human colon cancer cell lines, DLD-1 and HCT116, that do not express endogenous ETS1 protein and have obtained several independent clones. The expression of wild-type ETS1 protein in these colon cancer cells reverses the transformed phenotype and tumorigenicity in a dose-dependent manner. By contrast, expression in DLD-1 cells of a variant form of ETS1, lacking transcriptional activity, did not alter the tumorigenic properties of the cells, suggesting that the reduction in tumorigenicity in these clones was specific for the wild-type ETS1 gene products. Since these colon cancer cells have multiple genetic alterations, the system described in this paper could be a good model to study the suppression of tumorigenicity at a transcriptional level, which could lead to the design and development of novel drugs for cancer treatment. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-05-09
