Transcriptomic analysis of ASD and IDD associated pathogenic MYT1L S707Q mutation in human cortical interneurons

We have used our protocol for generating cortical interneurons from human stem cells to study gene expression changes caused by the (S707QfsX56) mutation in the MYT1L gene, using both patient derived (PD) and variant knock in (VKI) models. Overall design: For each cell line, 4 biological replicates generated from independant differentiations of human pluripotent stem cells were used for transcriptomic analysis by RNA-sequencing.