Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

We investigated whether variants fine-mapped for Rheumatoid Arthritis (RA) and Type 1 Diabetes overlap with open chromatin regions specifically after stimulation. We show that rs117701653, a potentially causal variant for RA near CD28, overlaps open chromatin regions only after stimulation. We futhermore observe a small increase in enhancer activity for this variant under stimulatory conditions using a luciferase assay. Reads were anonimized prior to upload. Examination of chromatin accesibility in CD4+ T-cells from a single individual at 8 timepoints after stimulation with anti-CD3/CD28 beads