Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-576 (5,6-dichloro-1H-1,3-benzodiazol-2-yl)methanol

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-576 (5,6-dichloro-1H-1,3-benzodiazol-2-yl)methanol Descriptor: (5,6-dichloro-1H-benzimidazol-2-yl)methanol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-02-25 Release date: 2017-02-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

甲型流感病毒WILSON-SMITH/1933株（H1N1亚型）聚合酶酸性蛋白（Polymerase Acid Protein, PA）与命中片段EBSI-576（(5,6-二氯-1H-1,3-苯并二唑-2-基)甲醇）结合的晶体结构
描述符：(5,6-二氯-1H-苯并咪唑-2-基)甲醇、氯离子、二甲基亚砜等
作者：西雅图传染病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID）
提交日期：2016-02-25
发布日期：2017-02-22
最后修改日期：2024-03-06
实验方法：X射线衍射（2.35埃）
引用文献：通过饱和转移差示核磁共振（STD NMR）片段筛选鉴定出针对甲型流感病毒聚合酶PA的新型位点结合剂，待发表。