Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin

Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020

pH 7.5条件下与甲基-β-环糊精（methyl beta-cyclodextrin）共结晶、并结合镍(II)离子（Ni(II)）的c-Src SH3结构域（c-Src SH3 domain）H122R-Q128E突变体的晶体结构
描述符：环状2,3-二-O-甲基-α-D-吡喃葡萄糖-(1→4)-2-O-甲基-α-D-吡喃葡萄糖-(1→4)-2,6-二-O-甲基-α-D-吡喃葡萄糖-(1→4)-2-O-甲基-α-D-吡喃葡萄糖-(1→4)-α-D-吡喃葡萄糖-(1→4)-α-D-吡喃葡萄糖-(1→4)-3-O-甲基-α-D-吡喃葡萄糖、镍(II)离子、原癌基因酪氨酸蛋白激酶Src（Proto-oncogene tyrosine-protein kinase Src）
作者：Camara-Artigas, A.
沉积日期：2020-01-26
发布日期：2020-04-22
最后修改日期：2024-01-24
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.05埃（Å）
引用文献：《工程化ATCUN基序（ATCUN motif）对c-Src酪氨酸激酶SH3结构域结构与生物物理特性的影响》，J.Biol.Inorg.Chem.，第25卷，2020年