Crystal structure of Compound 35 with ERK5

Crystal structure of Compound 35 with ERK5 Descriptor: Mitogen-activated protein kinase 7, [2-azanyl-4-(trifluoromethyloxy)phenyl]-[4-(7-methoxyquinazolin-4-yl)piperidin-1-yl]methanone Authors: Nguyen, D, Lemos, C, Wortmann, L, Eis, K, Holton, S.J, Boemer, U, Lechner, C, Prechtl, S, Suelze, D, Siegel, F, Prinz, F, Lesche, R, Nicke, B, Mumberg, D, Bauser, M, Haegebarth, A. Deposit date: 2018-09-07 Release date: 2019-02-27 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J. Med. Chem., 62, 2019

化合物35与ERK5的晶体结构（对应丝裂原活化蛋白激酶7（Mitogen-activated protein kinase 7））：[2-氨基-4-(三氟甲氧基)苯基]-[4-(7-甲氧基喹唑啉-4-基)哌啶-1-基]甲酮。作者：Nguyen, D、Lemos, C、Wortmann, L、Eis, K、Holton, S.J、Boemer, U、Lechner, C、Prechtl, S、Suelze, D、Siegel, F、Prinz, F、Lesche, R、Nicke, B、Mumberg, D、Bauser, M、Haegebarth, A。沉积日期：2018年9月7日；发布日期：2019年2月27日；最后修改日期：2024年5月15日。实验方法：X射线衍射（2.33埃）。引用文献：《强效高选择性基于(哌啶-4-基)吡啶并[3,2-d]嘧啶的ERK5激酶体外探针BAY-885的发现与表征》，《J. Med. Chem.》，62卷，2019年。