articles 02.csv

File contains manuscripts/abstracts to be uploaded to Rayyan without duplicates. Abstract: The growing demand for more efficient materials for medical applications brought together two previously distinct fields: medicine and engineering. Regenerative medicine has evolved with the engineering contributions to improve materials and devices for medical use. In this regard, graphene is one of the most promising materials for bone tissue engineering and its potential for bone repair has been studied by several research groups. The aim of this study is to conduct a scoping review including articles published in the last 12 years (from 2010 to 2022) that have used graphene and its derivatives (graphene oxide and reduced graphene) in preclinical studies for bone tissue regeneration, searching in PubMed/MEDLINE, Embase, Web of Science, Cochrane Central, and clinicaltrials.gov (to confirm no study has started with clinical trial). Boolean searches were performed using the defined key words “bone” and “graphene”, and manuscript abstracts were uploaded to Rayyan, a web-tool for systematic and scoping reviews. This scoping review was conducted based on Joanna Briggs Institute Manual for Scoping Reviews and the report follows the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses – Extension for Scoping Reviews (PRISMA-ScR) statement. After the search protocol and application of the inclusion criteria, 77 studies were selected and evaluated by five blinded researchers. Most of the selected studies used composite materials associated with graphene and its derivatives to natural and synthetic polymers, bioglass, and others. Although a variety of graphene materials were analyzed in these studies, they all concluded that graphene, its derivatives, and its composites improve bone repair processes by increasing osteoconductivity, osteoinductivity, new bone formation, and angiogenesis. Thus, this systematic review opens up new opportunities for the development of novel strategies for bone tissue engineering with graphene.

本文件包含待上传至Rayyan系统且无重复的手稿与摘要。摘要：医疗领域对高性能医用材料的需求日益增长，推动原本分野的医学与工程学两大领域实现交叉融合。再生医学借助工程学的技术支撑，不断优化医用材料与器械。就此而言，石墨烯是骨组织工程领域极具应用前景的材料之一，其骨修复潜力已被多个研究团队深入探索。本研究旨在开展一项范围综述（scoping review），纳入2010至2022年这12年间发表的、将石墨烯及其衍生物（氧化石墨烯与还原石墨烯）应用于骨组织再生临床前研究的相关文献。检索范围涵盖PubMed/MEDLINE、Embase、Web of Science、Cochrane Central以及clinicaltrials.gov数据库（用于确认尚无研究启动临床试验阶段）。研究采用预设关键词“bone”与“graphene”开展布尔逻辑检索，并将手稿摘要上传至用于系统综述与范围综述的在线工具Rayyan。本范围综述严格遵循《乔安娜·布里格斯研究所范围综述手册》开展，报告则遵照《系统综述与元分析报告规范——范围综述扩展版》（PRISMA-ScR）的推荐格式撰写。完成检索方案制定与纳入标准筛选后，共有77项研究被纳入，并由5名盲法研究人员进行评估。纳入的多数研究将石墨烯及其衍生物与天然聚合物、合成聚合物、生物玻璃等材料复合制备复合材料。尽管上述研究分析了多种石墨烯基材料，但所有研究均得出一致结论：石墨烯及其衍生物与复合材料可通过提升骨传导性、骨诱导性、新生骨形成能力与血管生成水平，有效促进骨修复过程。综上，本系统综述为基于石墨烯的骨组织工程创新策略开发提供了全新方向。