Inhibition of SFV and SINV replication by selected hit compounds measured by CPE reduction and virus production assays.

aIC50 values against SFV and SINV were determined in dose-response experiments using an assay for the reduction of cytopathic effect. A concentration range from 200 µM to 0.1 µM was applied for each compound. The results represent the mean values from two individual experiments, both run in triplicate (CV ranged from 9.9 to 18.6%).
cThe effect of hit compounds on SFV yield was analyzed by determining SFV titers of infection samples grown in the presence of 50 µM hit compound. The untreated control sample had an SFV titer of 1.4×109 PFU/ml. NC = natural compounds, PC = pharmaceutical compounds.