Dual Targeting of G9a and DNMT1 for the Treatment of Experimental Cholangiocarcinoma
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE144183
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资源简介：
Cholangiocarcinogenesis involves epigenetic abnormalities of great relevance. Both the histone methyltransferase G9A and the DNA methyltransferase DNMT1 are overexpressed in this tumor. We used microarrays to evaluate the global programme of gene expression in the human CCA cell line EGI-1 treated with CM272. This molecule is an epigenetic inhibitor that simultaneously targets the methyltransferase activities of G9a and DNMT1. EGI-1 cells treatment with CM272 (200nM) or vehicle (0.01% DMSO) for 48 hours. 4 samples
创建时间：
2020-11-02
