Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution

Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... Authors: Paranjpe, M.N, Polikanov, Y.S. Deposit date: 2022-09-20 Release date: 2022-12-21 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin. Nucleic Acids Res., 51, 2023

分辨率为2.70 Å的嗜热栖热菌（Thermus thermophilus）70S核糖体与信使RNA（mRNA）、脱酰基P位点甲硫氨酸转运RNA（tRNA^Met）以及热鲁宾（thermorubin）的复合物晶体结构。描述项：16S核糖体RNA、23S核糖体RNA、30S核糖体蛋白S10等。作者：帕兰杰（Paranjpe, M.N.）、波利卡诺夫（Polikanov, Y.S.）。提交日期：2022-09-20。发布日期：2022-12-21。最后修改日期：2025-03-19。实验方法：X射线衍射（2.7 Å）。引用文献：《核糖体靶向抗生素热鲁宾抑制翻译的分子机制解析》，《核酸研究（Nucleic Acids Res.）》，第51卷，2023年。