Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity
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https://zenodo.org/record/4387065
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资源简介：
The immunological role of lactate in antitumor immunity is not well understood. In this study, we report lactate treatment significantly augments antitumor efficacy of immune checkpoint blockade or T cell vaccine therapy in multiple tumor models. Single cell transcriptomics and flow cytometry analysis revealed an increased subpopulation of stem-like TCF-1-expressing CD8+ T cells upon lactate treatment.
创建时间：
2022-07-21
