Secondary analysis: results of gene-based replication in FHS for genes containing SNPs associated with CAC in the GENOA discovery cohort.

The number of LD blocks in each gene region used to correct for multiple testing are presented, as well as thresholds for significance in FHS. SNP, single nucleotide polymorphism; Chr, chromosome; Mb, megabases; MAF, minor allele frequency; Beta, beta coefficient; SE, standard error. Models were adjusted for the following covariates: age, sex, body mass index (BMI), pulse pressure, diabetes, systolic blood pressure (SBP), use of anti-hypertensive medications, use of lipid lowering medications, and LDL-cholesterol.