Multiomics analyses of somatic cell reprogramming into neural stem cells by PTF1A
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https://www.ncbi.nlm.nih.gov/sra/SRP453642
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资源简介：
How 3D genome organization regulates cell fate transition remains poorly understood at present. By multiomics analyses integrating the Hi-C data, PTF1A and CTCF DNA-binding profiles, H3K27ac modification, and gene expression, we demonstrate that 3D genome reorganization as a driving force instrumental for cellular transcription program changes and cell fate transitions, and highlight an essential role for PTF1A in orchestrating multiscale 3D genome remodeling during cell reprogramming.
创建时间：
2024-11-12
